Introduction to Bioprocess Control with Cedex Analyzers

Bioprocess control is a crucial aspect of biopharmaceutical manufacturing, ensuring the production of high-quality products. The Cedex Analyzer Family, developed by Roche CustomBiotech, offers a comprehensive solution for bioprocess control, providing tight control of biopharmaceutical manufacturing, testing flexibility, and detailed insights to improve yield and process.

Key Features of Cedex Analyzers

The Cedex Analyzer Family combines the functionalities of multiple instruments, delivering powerful testing capabilities with reduced workflow complexity. The key features of Cedex Analyzers include:

• Precise measurements of nutrients, metabolites, and cell morphology
• Broad and continuously growing test menu
• High-throughput analysis with minimal manual interaction
• Robust platforms for continuous operation in pharmaceutical process development and industrial production

Cedex Bio and Bio HT Analyzers

The Cedex Bio and Bio HT Analyzers are designed for control in process development and large-scale fermentation. These instruments offer:

• Small footprint and high impact
• Fast measurements and high efficiency
• Throughput of 50-100 tests per hour (Cedex Bio) and 150-300 tests per hour (Cedex Bio HT)
• Sample capacity of up to 8 samples at once (Cedex Bio) and up to 126 samples at once (Cedex Bio HT)

Comprehensive Test Menu

The Cedex Analyzer Family offers a comprehensive test menu, including:

• Substrates: Ala-Gln, Arabinose, Asparagine, Aspartate, Calcium, Cholesterol, Ethanol, Galactose, Glucose, Glutamate, Glutamine, Glycerol, Iron, Magnesium, Methanol, Nitrate, Phosphate, Potassium, Pyruvate, Sodium, Sucrose
• Metabolites: Acetate, Ammonia, Formate, Lactate, LDH, Osmolality calc., Urea
• Products: Ig Fab (human), IgG (human), Mouse IgG, Optical Density (bio mass), Total Protein

Data Integration and Cell Analysis

The Cedex Analyzers can be integrated with the Sm@rtline Data Cockpit, a software middleware that eases collection, review, and approval of trial results. Additionally, the Cedex HiRes Analyzer is a fully automated, image-based cell analyzer that provides information about cell concentration, viability, aggregates, and morphological parameters.

Conclusion

The Cedex Analyzer Family is a powerful tool for bioprocess control, offering a comprehensive solution for biopharmaceutical manufacturing. With its precise measurements, broad test menu, and high-throughput analysis, Cedex Analyzers enable informed decisions and fast response times, ultimately improving yield and process. For more information on Cedex Analyzers and bioprocess control, visit Roche CustomBiotech or contact your local CustomBiotech team.